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8110 Gatehouse Road, Falls Church, VA 22042

The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest: EPS ARREST


General Information

Age Group




Protocol Number


Background Information

The goal of the EPS ARREST study is to evaluate the diagnostic yield of a standardized invasive electrophysiology study among survivors of sudden cardiac death (SCD) when initial investigations fail to identify an underlying etiology. In addition, as we believe that cases of unexplained SCD often have a genetic component, it will also provide an opportunity to evaluate the yield of genetic testing and may potentially lead to the identification of additional genetic culprits in this patient population.

Participants will be asked to provide a blood sample to be stored for future genetic studies. For Canadian participants, this will be performed as part of the CASPER study. Learning more about the genetics of unexplained SCD may lead to improved care of affected patients and their family members.

Offered At

Inova Fairfax Hospital
3300 Gallows Road
Falls Church, VA 22042

Principal Investigator

Leonard Ilkhanoff, MD

Adam Strickberger, MD

Eligibility Information

  1. Unexplained cardiac arrest requiring cardioversion or defibrillation
  2. Patient undergoing EP study
  3. Willing and able to sign informed consent

Ineligibility Information

  1. Coronary artery disease and clinical findings consistent with an ischemic arrest
  2. Reduced left ventricular function on echocardiogram or cardiac MRI
  3. Persistent resting QTc > 460 msec for males and 480 msec for females
  4. Resting QTc < 350 msec
  5. Type I Brugada ECG with >/= 2 mm ST elevation in V1 and/or V2
  6. Polymorphic or bidirectional ventricular tachycardia
  7. Clinical, electrocardiographic, and/or imaging findings consistent with a diagnosis of arrhythmogenic right ventricular cardiomyopathy
  8. Myocarditis
  9. Reversible cause of cardiac arrest such as marked hypokalemia (< 2.8 mmol/l) or drug overdose sufficient in severity without other cause to explain the cardiac arrest
  10. Arrhythmic Mitral Valve Prolapse Syndrome
  11. Documented ventricular fibrillation induced by a short-coupled premature ventricular contraction