The purpose of this study is to identify gene changes that cause DCM and gene differences that influence the development and severity of DCM. These genetic studies may identify a change in a gene that has already been linked with DCM, a change in a gene not previously associated with DCM, or these studies may identify a gene or genes that affect the development and severity of the DCM. With this knowledge we hope to have a better understanding of how genes and gene changes cause DCM.
Inova Fairfax Hospital
3300 Gallows Road
Falls Church, VA 22042
Palak Shah, MD
Meeting criteria for dilated cardiomyopathy (DCM):
- Left ventricular ejection fraction <50%
- Left ventricular enlargement (A left ventricular end-diastolic dimension > 95%tile population standard based on gender and height)
- Detectable causes of cardiomyopathy, except genetic, excluded beyond a reasonable doubt at the time of DCM diagnosis (that is, meeting clinical criteria for idiopathic DCM)
- Any age (including children)
- Non-Hispanic and Hispanic ethnicity
- All races (PI pre-approval required for recruitment beyond pre-specified recruitment targets)
- Ability to give informed consent
- Ability to communicate in English (except Spanish language at sites approved to recruit individuals of Hispanic ethnicity)
- Willingness to participate in a family-based study (patient willing to work with a clinical site and/or OSU to facilitate the recruitment and enrollment of family members to the study).
- Coronary artery disease (CAD) causing ischemic cardiomyopathy (> 50% narrowing, any major epicardial coronary artery)
- Primary valvular disease
- Adriamycin or other cardiotoxic drug exposure
- Other forms of cardiomyopathy: Hypertrophic, Restrictive, or Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
- Congenital heart disease
- Other detectable causes of dilated cardiomyopathy, including sarcoid and hemochromatosis.
- Other active multi-system disease that may cause DCM (e.g., active connective tissue disease).
- Severe and untreated or untreatable hypertension (systolic blood pressures routinely greater than 180 mm Hg and/or diastolic blood pressures greater than 120 mm Hg, and if resistant to multidrug treatment).
- However, conventional risk factors for DCM, including obesity, routinely treated hypertension, alcohol use, pregnancy or the peri-partum period, or left ventricular noncompaction, will NOT be considered exclusion criteria.