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Please use the search below. See our frequently asked questions regarding clinical trials. 

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This trial seeks to evaluate the efficacy of Macitentan in patients with pulmonary hypertension after left-ventricular device (LVAD) implantation.

This study is a US-based, prospective, double-blind, multicenter, placebo-controlled, randomized 1:1, pulmonary hypertension in LVAD patients trial.


This study seeks to evaluate the effectiveness of sacubatril-valsartan (aka: Entresto) in patients with advanced heart failure.

This is a US, multicenter, placebo-controlled, HFrEF trial. Testing Entresto in patients with any history of NYHA IV symptoms. 26-week study to assess change in NT-proBNP. Sponsor: NIH HF Network.

Technology to improve drug Adherence and Reinforce Guideline based Exercise Targets in patients with Heart Failure and Diabetes Mellitus (TARGET-HF-DM)

Sponsor: American Heart Association and Duke Medicine

Heart failure and Diabetes share a common set of risk factors and both require ongoing lifestyle modification and adherence to complex medication regiments in order to achieve optimal outcomes. The study evaluates the utility of an mHealth (a mobile support of health related behaviors) intervention to improve physical activity and medication adherence in patients with both chronic heart failure and diabetes mellitus.

DCM Precision Medicine Study

The purpose of this study is to identify gene changes that cause DCM and gene differences that influence the development and severity of DCM. These genetic studies may identify a change in a gene that has already been linked with DCM, a change in a gene not previously associated with DCM, or these studies may identify a gene or genes that affect the development and severity of the DCM. With this knowledge we hope to have a better understanding of how genes and gene changes cause DCM.

A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease (SERENADE)

This is a study to evaluate whether macitentan is an effective and safe treatment for patients with heart failure with preserved ejection fraction (HFpEF) and pulmonary vascular disease. The primary objective is to evaluate whether macitentan 10 mg reduces N-terminal pro-brain natriuretic peptide (NT-pro-BNP) as compared to placebo in these patients.

Procyrion-The CRS Registry: An Observational Study of Patients Being Treated for Cardiorenal Syndrome

This is an observational study to collect information on treatment patterns and outcomes of patients with cardiorenal syndrome (CRS). This is characterized by acute decompensated heart failure (ADHF) and worsening renal function (WRF) with persistent congestion despite treatment with medical management. Medical records will be utilized to collect data regarding factors related to ADHF, kidney function, congestion and associated outcomes.

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