Clostridium difficile infection is an intestinal infection that can be life threatening. The incidence is increasing in children, and there is resistance to standard treatment with rising rates of recurrence. In resistant and recurrent cases, manipulation of the microbiome by FMT is an effective treatment. We are examining the intestinal microbiome in children before and after FMT to gain and better understanding of why this treatment is effective and also to improve FMT treatment in the future.
Pediatric Specialists of Virginia
3023 Hamaker Court
Fairfax, VA 22031
Inova Children's Hospital
Inova Fairfax Medical Campus
3300 Gallows Road
Falls Church, VA 22042
Suchi Hourigan, MD
- Children who have had at least 3 recurrences of Clostridium difficile infection and are clinically undergoing fecal microbiota transplantation. These can be children both with and without inflammatory bowel disease (IBD).
Hourigan SK, Chen LA, Grigoryan Z, Laroche G, Weidner M, Sears CL, Oliva-Hemker M. Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammatory bowel disease. Aliment Pharmacol Ther. 2015 Sep;42(6):741-52. http://www.ncbi.nlm.nih.gov/pubmed/26198180
Hourigan SK, Oliva-Hemker M. Fecal Microbiota Transplantation in Children - A Brief Review. Pediatr Res. 2016 Mar 16. [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/26982451