General Information

Age Group

Adults

Status

Recruiting

Protocol Number

NCT06745024

Background Information

The primary objective of this study is to determine whether prophylactic radiation therapy (RT) to high-risk asymptomatic bone metastases decreases the occurrence of skeletal-related events (SREs), including pathologic fracture, spinal cord compression, and surgery to bone (not including palliative radiation for pain only), compared to standard of care (SOC).

For more information visit: https://www.clinicaltrials.gov/study/NCT06745024

Offered At

4320 Seminary Road 
Alexandria, VA 22304
 

3600 Joseph Siewick Drive
Fairfax, VA 22033
 

44045 Riverside Pkwy
Leesburg, VA 20176
 

8081 Innovation Park Drive
Fairfax, VA 22031
Principal Investigator

Avani Rao, MD

Eligibility Information

  • Patients with polymetastatic cancer defined as more than 5 sites of radiographically-evident systemic metastatic disease (excluding intracranial disease)
  • Patients with any solid tumor type (excluding multiple myeloma)
  • Patients must have systemic disease evaluation through standard of care diagnostic imaging, including either CT chest/abdomen/pelvis or body positron emission tomography (PET)/CT, with radiology report available
  • Patients with treated brain metastases and no known leptomeningeal disease are eligible if these lesions have been treated prior to enrollment
  • Performance status: Eastern Cooperative Oncology Group (ECOG) 0-2 or Karnofsky performance status (KPS) ≥ 60

Ineligibility Information

  • Previous radiotherapy to the intended enrolled sites of disease
  • Epidural spinal cord compression (ESCC) ≥ grade 1c (defined as deformation of the thecal sac with spinal cord abutment) at the enrolled bone metastasis(es)