Clinical trials

Clostridium difficile infection is an intestinal infection that can be life threatening. The incidence is increasing in children, and there is resistance to standard treatment with rising rates of recurrence. In resistant and recurrent cases, manipulation of the microbiome by FMT is an effective treatment. We are examining the intestinal microbiome in children before and after FMT to gain and better understanding of why this treatment is effective and also to improve FMT treatment in the future.

This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome.

Heart failure is a condition where the heart muscle cannot pump blood effectively to meet the body's needs. Among children and adults with complex heart disease (congenital or acquired), heart failure is the main cause of death or heart transplantation. The purpose of the study is to evaluate heart failure progression among children from multiple sites around the world, to find the best ways to manage the disease and work towards long and healthy lives in this population.

Cardiac catheterization is a medical procedure that involves inserting a thin, flexible tube (catheter) into a blood vessel and threading it into the heart. Cardiac catheterization procedures may require access to the upper systemic chamber (left atrium) or lower systemic chamber (left ventricle) of the heart. Historically it was done using the artery in the groin (femoral artery), and now it is often approached via the femoral vein, using a puncture across the atrial wall (trasseptal puncture) to access the left side of the heart from the right side. The primary outcome is to assess transseptal puncture success and assess puncture related adverse events.

Flecainide is a medication used to prevent or treat irregular heartbeats. However, it may worsen existing irregular heartbeats or create new rhythm issues. This is why it is started in the inpatient setting among pediatric patients. The study aims to assess unintended medical occurrences that might happen and identify low-risk patients that can potentially start Flecainide outside of the hospital.

Iodinated contrast media (ICM) are substances containing iodine that are used in medical imaging procedures (such as X-rays, computed tomography [CT] scans, and cardiac catheterization with angiography). ICM are known to have toxic effects, however, their effect on thyroid function has not been fully studied. The purpose of the study is to determine the extent of thyroid dysfunction that follows ICM exposure in high-risk pediatric patients.

This clinical trial is for children on ExtraCorporeal Membrane Oxygenation (ECMO), a machine used to support the heart and lungs. This study evaluates the method in which ECMO patients are treated with Red Blood Cell (RBC) transfusions. Most ECMO centers provide RBC transfusions to maintain a certain hemoglobin (Hb) or hematocrit level for children on ECMO. However, the Hb/HCT level at which oxygen delivery is best is not known. This study evaluates RBC transfusion practice to improve treatment and outcomes for children requiring ECMO.

This study assesses how blood cell growth patterns (clonal hematopoiesis), relates to heart health or cardiovascular disease (CVD) after treatment in patients with Hodgkin lymphoma. In some patients, cancer treatment at a young age may lead to later complications, including problems with heart health. Checking for blood cell growth patterns called therapy-related clonal hematopoiesis (t-CH) can help predict who might be at risk for heart health problems after Hodgkin lymphoma treatment. If doctors know who may be at greater risk for developing later heart complications, then they can more closely monitor those patients to prevent or detect heart complications early.